Genetic Aspects and Gene Regulation

Image The current explosion of GWAS (Genome-Wide Association Study), driven in part by falling genotyping costs, has revealed some causal variants and others that have failed to replicate. In some cases, the observed linkage of associated SNPs to coding genes suggests that the associated variant might alter risk by regulating gene expression. cis-linked noncoding sequences often contain consensus binding sites for transcription factors, and recently, a causal variant for colorectal cancer was shown to be a cis-eQTL for SMAD... Read More